Custom Peptides
Cayman Chemical DIfelIkefalIntrIfluoROCTA 10mg
A κ-opioid receptor agonist; activates KOR in HEK293 cells expressing the human receptor (EC50 = 0.16 nM in a transactivation assay); inhibits forskolin-induced cAMP production in R1.G1 cells (EC50 = 0.048 nM); selective for KOR over MOR (EC50 = >1 µM in a transactivation assay); reduces acetic acid-induced writhing, as well as GNTI-induced scratching behavior, in mice (ED50s = 0.07 and 0.05 mg/kg, respectively)
Cayman Chemical npIcastathydrochlorIde 10mg
An inhibitor of DBH (IC50 = 9 nM for the purified human enzyme); selective for DBH over a panel of 12 enzymes and 13 neurotransmitter receptors (IC50s or Kis = >10 μM); dose-dependently reduces norepinephrine content and increases dopamine content in the mesenteric artery, left ventricle, and cerebral cortex in spontaneously hypertensive rats, as well as in the renal artery, left ventricle, and cerebral cortex in beagle dogs; attenuates increases in diastolic blood pressure and heart rate induced by preganglionic sympathetic nerve stimulation in pithed spontaneously hypertensive rats at 10 and 30 mg/kg; reduces the progressive ratio response for cocaine, but not food or sucrose pellets, in rats at 50 mg/kg; reduces reinstatement of cocaine-seeking behavior induced by cues, yohimbine, or foot-shock in rats
Cayman Chemical AmsacrInhydrochlorIde 10mg
A topoisomerase II poison; stimulates formation of a complex between DNA and topoisomerase II in which the DNA is cleaved and topoisomerase II remains covalently linked to the 5’ end of the DNA cleavage products; inhibits the DNA strand-passing activity of topoisomerase II at a concentration of 20 μg/ml; reduces growth of LoVo human colorrectal carcinoma and T1 human lymphoma cells in a dose-dependent manner; antitumor activity against several murine leukemia, melanoma, lung, colon, and mammary xenograft mouse models
Cayman Chemical PRfluorohexnsulfonIc AcId 10mg
A perfluoroalkyl substance; activates PPARα in a reporter assay using COS-1 cells expressing the human or mouse receptor from 5-100 µM; has been found in landfill leachate and sea and river water
Cayman Chemical TG11-77hydrochlorIde 10mg
An EP2 receptor antagonist (KB = 9.7 nM); selective for EP2 over DP1, EP4, and IP receptors (KBs = 7,320, 5,300, and >10,000 nM, respectively); inhibits the expression of genes encoding COX-2, IL-1β, and IL-6 induced by LPS and the EP2 receptor agonist ONO-AE1-259-01 in mouse BV-2 microglia expressing human EP2 receptors at 0.3 and 1 μM
Cayman Chemical OctreotIdeacetate 10mg
A somatostatin receptor agonist (Kis = 875, 0.57, 26.8, >1,000, and 6.8 nM for SST1-5 receptors, respectively); selectively binds to SST2 over SST3 and SST5 receptors (IC50s = 0.02, 92.9, and 21.8 nM, respectively); inhibits the secretion of growth hormone in vitro in rat pituitary cells three-fold more potently than somatostatin; inhibits the secretion of growth hormone in vivo in rhesus monkey (ID50 = 0.38 UG/kg per hour); inhibits proliferation of VEGF-stimulated human umbilical endothelial cells (HUVECs) with an EC50 value of approximately 1 µM; inhibits growth of LCI-D20 human hepatocellular carcinoma cell tumors in a nude mouse xenograft model when administered at a dose of 50 UG/kg twice daily
Cayman Chemical Sulfonadyn-47 10mg
A dynamin inhibitor; inhibits dynamin GTPase activity in a cell-free assay (IC50 = 3.5 µM); inhibits clathrin-mediated endocytosis in U2OS cells (IC50 = 27.3 µM), as well depolarization-stimulated uptake of FM4-64 in isolated rat brain synaptosomes (IC50 = 12.3 µM); has anticonvulsant activity in the 6 Hz corneal kindling mouse model of seizures at 30 and 60 mg/kg
Cayman Chemical 3hydroxy StarIc ACD mthyl 10mg
A hydroxy fatty acid methyl ester; has been found in PHA polymers produced by Streptomyces sp. JM3 and in trace amounts in M. bijuga fruit; chemical scent constituent in feces of adult wild Iberian wolves (C. lupus signatus)
Cayman Chemical 15hydroxy PentadecNIc ACD 10mg
A hydroxylated fatty acid; has been used in the synthesis of the macrocyclic lactone musk compounds exaltolide and phoracantholide I
Cayman Chemical UNC2170maleate 10mg
A micromolar ligand of 53BP1 that binds to a pocket formed by the tandem tudor domains on a 53BP1 homodimer; functions as a 53BP1 antagonist in cellular lysates
Cayman Chemical SynthetIc KhasInIn 10mg
A steroidal glycoside with diverse biological activities; reduces the proliferation of LNCaP and T47D cancer cells (IC50s = 32.1 and 27.5 µM, respectively); inhibits TNF-α-induced nuclear translocation of NF-κB in HaCaT keratinocytes at 50 nM; decreases AST serum levels in a mouse model of carbon tetrachloride-induced liver injury at 0.1 mg/kg; topical administration reduces EAr epidermal thickness and scaling, as well as leukocyte and macrophage infiltration, in an imiquimod-induced mouse model of psoriasis at 5 mg/kg
Cayman Chemical SynthetIc Curzeren 10mg
A sesquiterpene with diverse biological activities; scavenges DPPH radicals in a cell-free assay at 3.36 UG/L with a synergistic effect when used in combination with eucalyptol; active against F. graminearum at 0.5 mg/ml; inhibits the proliferation of SK-MEL-19 melanoma cells (IC50 = 5.17 UG/ml), as well as AGP-01 gastric and HCT116 colon cancer cells (IC50s = 8.04 and 9.18 UG/ml, respectively) and MRC-5 non-cancerous human fibroblasts (IC50 = 11.45 UG/ml); induces apoptosis in, and decreases migration of, SK-MEL-19 cells at 5 and 10 µM; reduces tumor weight in an SPC-A1 mouse xenograft model at 135 mg/kg
Cayman Chemical Bluma balsamfra Blumatn 10mg
A flavonoid with antioxidant and anticancer activities; scavenges DPPH radicals in a cell-free assay (SC50 = 90.8 UG/ml); decreases carbon tetrachloride-induced lipid peroxidation in isolated rhesus monkey hepatocytes; cytotoxic to KB oral carcinoma cells (IC50 = 47.72 UG/ml)
Cayman Chemical NdSmethyl DIltIazemhydroc 10mg
An active metabolite of diltiazem; binds to isolated rat cerebral cortex homogenates (IC50 = 323 nM); inhibits spontaneous contractions in isolated rat portal veins (IC50 = 489 nM); has been found as a contaminant in fresh water